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Pharmaceutical Organic Chemistry II (BP301T)

Unit IV – Polynuclear Hydrocarbons

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1. Introduction to Polynuclear Hydrocarbons

Polynuclear hydrocarbons are aromatic compounds containing two or more fused benzene rings. They exhibit aromatic character and unique chemical reactivity.

2. Classification

3. Naphthalene

Naphthalene consists of two fused benzene rings. It undergoes electrophilic substitution reactions mainly at the alpha position.

4. Reactions of Naphthalene

5. Anthracene

Anthracene contains three fused benzene rings in a linear arrangement. It is reactive at the 9 and 10 positions.

6. Phenanthrene

Phenanthrene consists of three fused benzene rings arranged angularly. It is more stable compared to anthracene.

7. Chemical Properties

8. Pharmaceutical Importance

Many biologically active compounds and drugs contain fused aromatic systems. Understanding polynuclear hydrocarbons helps in medicinal chemistry and drug design.