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Pathophysiology (BP204T)

Unit II – Inflammation & Immunity

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1. Introduction to Inflammation

Inflammation is a protective response of the body to injury or infection. It aims to eliminate the initial cause of cell injury, remove damaged tissue, and initiate the healing process.

2. Types of Inflammation

3. Cardinal Signs of Inflammation

4. Chemical Mediators of Inflammation

Chemical mediators are substances that initiate and regulate inflammatory reactions. These include histamine, serotonin, prostaglandins, leukotrienes, cytokines, and complement proteins.

5. Acute Inflammatory Response

Acute inflammation is characterized by rapid onset and short duration. It involves increased vascular permeability and migration of leukocytes to the site of injury.

6. Chronic Inflammation

Chronic inflammation is prolonged and may result from persistent infections, autoimmune diseases, or prolonged exposure to toxic agents. It leads to tissue destruction and fibrosis.

7. Introduction to Immunity

Immunity is the ability of the body to resist infections and diseases. It involves recognition and elimination of foreign substances called antigens.

8. Types of Immunity

9. Immune Response

Immune response involves activation of immune cells such as lymphocytes, macrophages, and antigen-presenting cells to destroy pathogens.

10. Pharmaceutical Importance

Understanding inflammation and immunity is essential for the use of anti-inflammatory drugs, immunosuppressants, vaccines, and immunomodulators in disease management.